the only point is: natural breeding sounds better but its technically the same.
you can select any natural-mutation based on a radiation damage on the genetic with natural breeding and in the end there is nothing "natural" its only a effect of the radiation and mutation.
Direct genetic manipulation is the same like a mutation because of (natural)radiation its only faster.
Natural mutation or direct Genetic manipulation do not chance this: "the plant tests it itself - by surviving or not."
The plant still tests itself by surviving or not.
this basic rule is not off just because you manipulate the genetic code.
(only you use the BAD stuff termination technology then its broken by design)