And I game with my AMD card. Granted, this is mostly native gaming, but I do game and game often on the free R600 Gallium3D drivers and this is with the stock drivers available on Fedora 16; not the latest git. I am looking forward to the improvements I will experience with Fedora 18 in November, but I am quite happy with the performance I have now. A little slower than I would get on the blobs, but I make up for that with ease of use and better support.
And the WINE thing is a bit of a red herring as I remember reading in another thread awhile back that part of the reason that Nvidia cards have an advantage is that back in the day they specifically coded Nvidia specific binary hacks into WINE to optimize performance on Nvidia cards. Not sure if I can dig up the thread again, but it was mentioned.