The Gigabyte GA-H110M-A is the first Skylake / LGA-1151 motherboard to fail on me in production use. I had bought this sub-$60 (USD) micro-ATX Skylake motherboard back in November where it's been running with a Pentium G4400 ever since.
This system has been devoted to our daily benchmarks of Clear Linux for the past few months for our daily benchmarks of this rolling-release distribution on LinuxBenchmarking.com.
Over a week ago I noticed the system going M.I.A. according to the Phoromatic alerts. After investigating, the system's fans would power up for a second or so and then power cycle. After swapping the PSU for safe measure, the issue persisted and the system never POST'ed while it had been running fine for all of these months prior.
I ordered a different LGA-1151 motherboard and it has since arrived. Once swapping out the motherboard (to an MSI motherboard, will cover it on Phoronix in the week ahead) and keeping all other components, it's been working fine without any problems. When inspecting the old Gigabyte H110M-A motherboard, I couldn't spot any electrical damage or other issues.