This weekend there was a new release of Wine-Mono, a project which marries Wine with components of Mono.
Wine-Mono is a package that provides Mono and other code to serve as a .NET run-time and class library implementation for Wine. The Wine-Mono runtime/libraries work with Wine's built-in .NET framework library.
When using this new Wine-Mono 0.0.4 release on Wine 1.5.4+, there is now support for mixed-mode assemblies, a replacement for XNA 4.0 based on MonoGame, the Mono code is updated to Mono 2.11.1, build script improvements, and other work.
Additional information on Wine-Mono 0.0.4 is available from the wine-devel mailing list