I use WASD like everyone else. It isn't that restricting, and generally there isn't many games I play that use that control scheme anyway. For RPGs I map all keys to the numpad. The last FPS I played was FarCry 3 and then all you need is 1,2,3 above WASD for weapon switch, CTRL and SHIFT.
Meta key doesn't really get it in the way. With my right hand my little finger is on SPACE, thumb for CTRL and SHIFT.