Except for some of the display options it looks like Gnomes setup.
You drag the monitors around so that they match their physical configuration and you can set things like primary monitor, resolution, etc. Also, it saves the setups so that when it detects those inputs again it automatically uses the setup you used previously.
I'm not the hugest fan of KDE, but after watching this video KDE clearly has far superior multimonitor support compared to any of the other DE's.
First official release: http://www.afiestas.org/kscreen-0-1-alpha-released/
This program is included in the Fedora 19 Beta, if you use KDE as your desktop. It looks like multiple video cards and multiple monitors is working with it using the nouveau driver. Seems to work perfectly so far...